reimbursement and cross-border
shortages, long waitlists, and rising drug costs as breakthrough therapies in oncology, obesity, and rare diseases challenge payers to design outcomes-based reimbursement and cross-border trial recruitment, while the WHO urges countries to close immunization gaps and modernize surveillance to catch outbreaks earlier; climate remains a throughline: heat waves strain grids and public transport, wildfire smoke disrupts aviation and outdoor work, and insurers reassess catastrophe exposure, retreating from high-risk markets and forcing conversations about public backstops and resilient building
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